SH2B2 Peptide
产品名称： SH2B2 Peptide
英文名称： SH2B2 Peptide
产品编号： P2797
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
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- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SH2B2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y629 of human SH2B2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling.
Li M, Li Z, Morris DL, Rui L.Endocrinology. 2007 Apr;148(4):1615-21. Epub 2007 Jan 4.
- 2.
- Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.
Katsanakis KD, Pillay TS.J Biol Chem. 2005 Nov 11;280(45):37827-32. Epub 2005 Sep 1.
- 3.
- APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation.
Iseki M, Kubo-Akashi C, Kwon SM, Yamaguchi A, Takatsu K, Takaki S.Biochem Biophys Res Commun. 2005 May 13;330(3):1005-13.
- Entrez GeneID:
- 10603
- Protein Accession#:
- NP_066189;O14492
- Gene Name:
- SH2B2
- Gene Alias:
- APS
- Gene Description:
- SH2B adaptor protein 2
- Omim ID:
- 605300
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq
- Other Designations:
- adaptor protein with pleckstrin homology and src homology 2 domains
- Related Disease