ZMPSTE24 polyclonal antibody
产品名称： ZMPSTE24 polyclonal antibody
英文名称： ZMPSTE24 polyclonal antibody
产品编号： PAB11975
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ZMPSTE24.
- Immunogen:
- A synthetic peptide corresponding to amino acids 1-100 of human ZMPSTE24.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Primates, Zebra fish
- Specificity:
- This antibody is specific to ZMPSTE24.
- Form:
- Liquid
- Storage Buffer:
- In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.
Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG.Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13432-7. Epub 2007 Jul 25.
- 2.
- Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.
Young SG, Fong LG, Michaelis S.J Lipid Res. 2005 Dec;46(12):2531-58. Epub 2005 Oct 5.
- 3.
- Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24.
Corrigan DP, Kuszczak D, Rusinol AE, Thewke DP, Hrycyna CA, Michaelis S, Sinensky MS.Biochem J. 2005 Apr 1;387(Pt 1):129-38.
- Entrez GeneID:
- 10269
- Protein Accession#:
- O75844
- Gene Name:
- ZMPSTE24
- Gene Alias:
- FACE-1,FACE1,FLJ14968,STE24,Ste24p
- Gene Description:
- zinc metallopeptidase (STE24 homolog, S. cerevisiae)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq
- Other Designations:
- CAAX prenyl protease,OTTHUMP00000006394,farnesylated-proteins converting enzyme 1,prenyl protein-specific endoprotease 1,zinc metalloproteinase STE24