FITC标记的磷酸化组蛋白去乙酰化酶4(Ser246)抗体
产品名称： FITC标记的磷酸化组蛋白去乙酰化酶4(Ser246)抗体
英文名称： Anti-Phospho-HDAC4 (Ser246)/FITC
产品编号： HZ-10325R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Phospho-HDAC4 (Ser246)/FITC Conjugated antibody
FITC标记的磷酸化组蛋白去乙酰化酶4(Ser246)抗体
| 英文名称 | Anti-Phospho-HDAC4 (Ser246)/FITC |
| 中文名称 | FITC标记的磷酸化组蛋白去乙酰化酶4(Ser246)抗体 |
| 别 名 | HDAC4(Phospho-Ser246); HDAC4(Phospho-S246); p-HDAC4(Ser246); p-HDAC4(S246); HD 4; HD4; HDAC 4; HDAC A; HDACA; Histone Deacetylase 4; Histone Deacetylase A; KIAA0288; EC 3.5.1.98; HA6116; HDA4_CAEEL; Histone deacetylase 4; CeHDA-7; Histone deacetylase 7. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 119kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human HDAC4 around the phosphorylation site of Ser246 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]. Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Subunit: Interacts with HDAC7. Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B. Interacts with KDM5B. Interacts with MYOCD. Interacts with MORC2. Interacts with ANKRA2. Subcellular Location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350 impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3. Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4. DISEASE: Brachydactyly-mental retardation syndrome (BDMR) [MIM:600430]: A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily. Database links: Entrez Gene: 9759 Human Entrez Gene: 208727 Mouse Entrez Gene: 363287 Rat Omim: 605314 Human SwissProt: P56524 Human SwissProt: Q6NZM9 Mouse SwissProt: Q99P99 Rat Unigene: 20516 Human Unigene: 318567 Mouse Unigene: 23483 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
组蛋白在转录调控、细胞周期进程和发育事件中起着关键作用。Histone乙酰化/去乙酰化改变染色体结构，影响转录因子对DNA的访问。该基因编码的蛋白属于组蛋白去乙酰化酶/ACUC/APHA家族的II类。它具有组蛋白去乙酰化酶活性和抑制转录时拴在启动子上。该蛋白不直接与DNA结合，而是通过转录因子MEF2C和MEF2D与DNA结合。[ RefSeq，JUL 2008 ]提供。