KNG1 monoclonal antibody (M02), clone 4A1
产品名称： KNG1 monoclonal antibody (M02), clone 4A1
英文名称： KNG1 monoclonal antibody (M02), clone 4A1
产品编号： H00003827-M02
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant KNG1.
- Immunogen:
- KNG1 (NP_000884.1, 322 a.a. ~ 427 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- VARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTSHLRSCEYKGRPPKAGAEPASEREVS
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.4 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Recombinant protein)
- Protocol Download
- Immunoprecipitation
- Immunoprecipitation of KNG1 transfected lysate using anti-KNG1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with KNG1 MaxPab rabbit polyclonal antibody.
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged KNG1 is 1 ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 3827
- GeneBank Accession#:
- NM_000893
- Protein Accession#:
- NP_000884.1
- Gene Name:
- KNG1
- Gene Alias:
- BDK,KNG
- Gene Description:
- kininogen 1
- Omim ID:
- 228960
- Gene Ontology:
- Hyperlink
- Gene Summary:
- High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond (Merkulov et al., 2008 [PubMed 18000168]).[supplied by OMIM
- Other Designations:
- alpha-2-thiol proteinase inhibitor,bradykinin
- Gene Pathway
- Related Disease
- Arrhythmias, Cardiac
- Blood Coagulation Disorders, Inherited
- Cardiovascular Diseases
- Coronary Artery Disease
- Coronary Disease
- Death, Sudden, Cardiac
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Edema
- Genetic Predisposition to Disease
- Hypertension
- Mental Disorders
- Obesity
- Obesity
- Thrombosis
- Tobacco Use Disorder