PFKFB1 (N-term) Peptide
产品名称： PFKFB1 (N-term) Peptide
英文名称： PFKFB1 (N-term) Peptide
产品编号： P3174
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PFKFB1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PFKFB1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Lange AJ, Pilkis SJ.Nucleic Acids Res. 1990 Jun 25;18(12):3652.
- 2.
- Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.
Algaier J, Uyeda K.Biochem Biophys Res Commun. 1988 May 31;153(1):328-33.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of PFKFB1 polyclonal antibody (Cat # PAB4020) in Jurkat cell lysate (35 ug/lane). PFKFB1 (arrow) was detected using the purified polyclonal antibody (1 : 240 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with PFKFB1 polyclonal antibody (Cat # PAB4020) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 5207
- Protein Accession#:
- F261_HUMAN
- Gene Name:
- PFKFB1
- Gene Alias:
- F6PK,HL2K,MGC116715,MGC116717,PFRX
- Gene Description:
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- Omim ID:
- 311790
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. [provided by RefSeq
- Other Designations:
- 6PF-2-K/Fru-2,6-P2ASE liver isozyme,OTTHUMP00000023391,fructose-2,6-bisphosphatase,fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
- Gene Pathway
- Related Disease