CREB1 (phospho S133) Peptide
产品名称： CREB1 (phospho S133) Peptide
英文名称： CREB1 (phospho S133) Peptide
产品编号： P1305
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of CREB1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S133 of human CREB1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen.
Samten B, Howard ST, Weis SE, Wu S, Shams H, Townsend JC, Safi H, Barnes PF.J Immunol. 2005 May 15;174(10):6357-63.
- 2.
- Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues.
Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, Chen H, Jenner R, Herbolsheimer E, Jacobsen E, Kadam S, Ecker JR, Emerson B, Hogenesch JB, Unterman T, Young RA, Montminy M.Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4459-64. Epub 2005 Mar 7.
- 3.
- Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells.
Cho KN, Choi JY, Kim CH, Baek SJ, Chung KC, Moon UY, Kim KS, Lee WJ, Koo JS, Yoon JH.J Biol Chem. 2005 Feb 25;280(8):6676-81. Epub 2004 Dec 21.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of CREB1 (phospho S133) polyclonal antibody (Cat # PAB0445) in CEM cell lysate (35ug/lane). Phospho-CREB1-S133 (arrow) was detected using the purified polyclonal antibody (1 : 40 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with CREB1 (phospho S133) polyclonal antibody (Cat # PAB0445) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 1385
- Protein Accession#:
- NP_604391;P16220
- Gene Name:
- CREB1
- Gene Alias:
- CREB,MGC9284
- Gene Description:
- cAMP responsive element binding protein 1
- Omim ID:
- 123810
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- active transcription factor CREB,cAMP-response element-binding protein-1,transactivator protein
- Related Disease
- Alcoholism
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- Diabetes Mellitus
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- Disease Models, Animal
- Dominance, Cerebral