LIMK1 polyclonal antibody
产品名称： LIMK1 polyclonal antibody
英文名称： LIMK1 polyclonal antibody
产品编号： PAB18112
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of LIMK1.
- Immunogen:
- A synthetic peptide corresponding to human LIMK1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to LIMK1.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms.
Croft DR, Olson MF.Mol Cell Biol. 2006 Jun;26(12):4612-27.
- 2.
- Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly.
Chen X, Macara IG.J Cell Biol. 2006 Feb 27;172(5):671-8.
- 3.
- Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.
Croft DR, Coleman ML, Li S, Robertson D, Sullivan T, Stewart CL, Olson MF.J Cell Biol. 2005 Jan 17;168(2):245-55.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from COS-7 cells, using LIMK1 polyclonal antibody (Cat # PAB18112).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 3984
- Protein Accession#:
- P53667
- Gene Name:
- LIMK1
- Gene Alias:
- LIMK
- Gene Description:
- LIM domain kinase 1
- Omim ID:
- 601329
- Gene Ontology:
- Hyperlink
- Gene Summary:
- There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. [provided by RefSeq
- Other Designations:
- LIM motif-containing protein kinase,OTTHUMP00000025066